Conformal meshing should be used for non-Manhattan polygons. Manhattan polygons are polygons which only have vertical and horizontal edges, no diagonals or curves. For these types of polygons, rectangular subsections are more efficient.
You should look at your geometry and, if necessary, divide it up into Manhattan and non-Manhattan polygons using the Edit Þ Divide Polygon. Then set the Manhattan polygons to staircase fill and the non-Manhattan polygons to Conformal fill. For example, the spiral conductor shown below contains Manhattan sections in the feedlines and non-Manhattan sections in the circular spiral. It should be divided up such that the feedlines are represented by polygons set to staircase fill, and the circular spiral is another polygon set to Conformal fill.
The exception to this rule is when relatively small Manhattan polygons are between conformal mesh polygons. In that case, the inefficiency of switching so frequently between staircase and conformal mesh outweighs the gain of using Manhattan polygons. In that case, conformal mesh should be applied to all the polygons. An example is shown below.